Rheumatoid arthritis (RA) is an incurable disease and lifelong therapy is required. Long term use of conventional synthetic drugs is associated with a spectrum of toxic effects. All the plants of the present polyherbal formulation have been traditionally used for the treatment of joint pain and rheumatoid arthritis. The present study was aimed to evaluate the anti-arthritic effect of polyherbal formulation by freund’s adjuvant induced arthritic rat model. The proposed polyherbal formulation comprising eight different medicinal plants which are traditionally used for inflammation, joint pain and rheumatoid arthritis. Selected plants parts were collected, dried, extracted and by using these extracts polyherbal formulation, namely SJT-RA-06 was prepared which was evaluated by Complete Fraud’s Adjuvant (CFA) induced arthritis in Wistar albino rats. The degree of inflammation was evaluated by hind paw swelling, body weight, arthritic index and various biochemical and hematological parameters. Histopathologies of ankle joints were also studied. SJT-RA-06 has shown significant reduction (p<0.001) in paw swelling, arthritic index and various biochemical parameters in serum as compared with arthritic control animals in CFA induced RA. These results were supported histological evaluation of joints. In conclude, proposed herbal formulation, SJT-RA-06 possess significant anti-arthritic activity by inhibiting various inflammatory mediators like histamine, bradykinin, PGE2, interleukins and thereby by act on multiple targets to achieve optimal effect.
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